If you are new to learning about defending yourself with a firearm, let me answer that question and save you from having to do any research.   The answer that you will come to if you choose not to read further and decide to research on your own is NO!   Using something as lethal as an Ar15 inside your home makes more sense than using any caliber handgun.

Sometimes when people think about defending themselves inside their home, the first thing that pops into their head is a revolver or some sort of handgun.   I still don’t understand that microscopic attitude towards defending oneself, but it is very common.    The real value of using a small M4 type firearm inside your home as the ability to weild it more effectively.  Give the least trained gun owner you know and give them an M4 and tell them to take out a target at 9 ft vs giving them a Glock.  If you’ve got a target model AR15, try swapping the AR15 Upper for an A2 style variant.